Use Of Hydroxypropyl- And Hydroxyethyl-derivatized Β-cyclodextrins For The Thin-layer Chromatographic Separation Of Enantiomers And Diastereomers
Partially substituted hydroxypropyl-β-cyclodextrin and hydroxyethyl-β-cyclodextrin proved to be effective chiral mobile phase additives (CMAs) for the thin-layer chromatographic (TLC) resolution of racemic benzyl-2-oxazolidinone, 5-(4-methylphenyl)-5-phenylhydantoin, mephenytoin and several dansyl and β-naphthylamide amino acies. Several diastereomeric compounds including steroid epimers and alkaloids were separated as well. The derivatized β-cyclodextrins tended to be much more soluble in water and hydro-organic solvents than native β-cyclodextrin. Their chromatographic selectivity also was somewhat different. The use of CMAs in TLC is a potentially useful and powerful method that has not been considered adquately. The relative lack of chiral stationary phases available in planar format makes the use of CMAs particularly attractive. © 1988.
D. W. Armstrong et al., "Use Of Hydroxypropyl- And Hydroxyethyl-derivatized Β-cyclodextrins For The Thin-layer Chromatographic Separation Of Enantiomers And Diastereomers," Journal of Chromatography A, vol. 452, pp. 323 - 330, Elsevier, Oct 1988.
The definitive version is available at https://doi.org/10.1016/S0021-9673(01)81457-6
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28 Oct 1988