Use Of Hydroxypropyl- And Hydroxyethyl-derivatized Β-cyclodextrins For The Thin-layer Chromatographic Separation Of Enantiomers And Diastereomers

Author

Daniel W. Armstrong, Missouri University of Science and Technology
James R. Faulkner Jr.
Soon M. Han

Abstract

Partially substituted hydroxypropyl-β-cyclodextrin and hydroxyethyl-β-cyclodextrin proved to be effective chiral mobile phase additives (CMAs) for the thin-layer chromatographic (TLC) resolution of racemic benzyl-2-oxazolidinone, 5-(4-methylphenyl)-5-phenylhydantoin, mephenytoin and several dansyl and β-naphthylamide amino acies. Several diastereomeric compounds including steroid epimers and alkaloids were separated as well. The derivatized β-cyclodextrins tended to be much more soluble in water and hydro-organic solvents than native β-cyclodextrin. Their chromatographic selectivity also was somewhat different. The use of CMAs in TLC is a potentially useful and powerful method that has not been considered adquately. The relative lack of chiral stationary phases available in planar format makes the use of CMAs particularly attractive. © 1988.

Recommended Citation

D. W. Armstrong et al., "Use Of Hydroxypropyl- And Hydroxyethyl-derivatized Β-cyclodextrins For The Thin-layer Chromatographic Separation Of Enantiomers And Diastereomers," Journal of Chromatography A, vol. 452, pp. 323 - 330, Elsevier, Oct 1988.

The definitive version is available at https://doi.org/10.1016/S0021-9673(01)81457-6

Department(s)

Chemistry

Comments

National Institute of General Medical Sciences, Grant R01GM036292

International Standard Serial Number (ISSN)

0021-9673

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2023 Elsevier, All rights reserved.

Publication Date

28 Oct 1988

PubMed ID

3243848