Several different derivatized β-cyclodextrins were synthesized and used as chiral stationary phases in normal-phase liquid chromatography. The multiply substituted derivatives were made with acetic anhydride, (R)-and (S)-1-(1-naphthyl) ethyl isocyanate, 2, 6-dimethylphenyl isocyanate, and p-toluoyl chloride. The first successful cyclodextrln-based, normal-phase separation of enantiomers was accomplished on these derivative phases. In contrast to chiral separations on the native β-cyclodextrin stationary phase, the enantiomeric separation mechanism on these new phases is not thought to be dependent on inclusion complexation. The similarities and differences between the derivatized cyclodextrin stationary phases and the cellulosic stationary phases are discussed. © 1990, American Chemical Society. All rights reserved.
D. W. Armstrong et al., "Derivatized Cyclodextrins For Normal-Phase Liquid Chromatographic Separation Of Enantiorners," Analytical Chemistry, vol. 62, no. 15, pp. 1610 - 1615, American Chemical Society, Jan 1990.
The definitive version is available at https://doi.org/10.1021/ac00214a014
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01 Jan 1990