Use Of A Three-phase Model With Hydroxypropyl-βy̧clodextrin For The Direct Determination Of Large Octanol-water And Cyclodextrin-water Partition Coefficients
A shake-flask method is presented which uses a three-phase model to measure octanol-water and cyclodextrin-water partition coefficients. Equations are derived which account for all equilibria and which relate the cyclodextrin-water partition coefficient to the formation constant for a cyclodextrin-solute complex. The partition coefficients of three aromatic solutes were determined and these values compared well with previously published partition coefficients. Solute concentration was determined using liquid chromatography. © 1991.
R. A. Menges and D. W. Armstrong, "Use Of A Three-phase Model With Hydroxypropyl-βy̧clodextrin For The Direct Determination Of Large Octanol-water And Cyclodextrin-water Partition Coefficients," Analytica Chimica Acta, vol. 255, no. 1, pp. 157 - 162, Elsevier, Dec 1991.
The definitive version is available at https://doi.org/10.1016/0003-2670(91)85101-W
Keywords and Phrases
Cyclodextrins; Hydroxypropyl-β-cyclodextrin; Liquid chromatography; Partition coefficients; Shake-flask method
International Standard Serial Number (ISSN)
Article - Journal
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05 Dec 1991