Reduced Cortical Surface Area in Multiple Sclerosis
Objective: to Assess Utility of Cortical Surface Area as a Measure of Disease Progression in Multiple Sclerosis (MS). Methods: We Measured Two-Dimensional Flattened Cortical Surface Area on High-Resolution Magnetic Resonance Imaging (MRI) Scans Obtained in 15 Subjects with Clinically Definite MS and Ten Normal Subjects. Results and Discussion: Single Hemisphere Cortical Area Was Reduced in MS Patients Compared with Controls (96,451 Versus 71,710 Mm2). We Found No Significant Relationship of Cortical Surface Area to Disability or Disease Duration. T2 Lesion Load Was Negatively Correlated with Two-Dimensional Cortical Surface Area (R= -0.62). Conclusion: Cortical Surface Area is Decreased in MS and May Be a Useful Measure of Disease Progression. © 2007 W. S. Maney & Son Ltd.
D. B. Hier and J. Wang, "Reduced Cortical Surface Area in Multiple Sclerosis," Neurological Research, vol. 29, no. 3, pp. 231 - 232, Taylor and Francis Group; Taylor and Francis, Apr 2007.
The definitive version is available at https://doi.org/10.1179/174313206X154003
Keywords and Phrases
Cortical atrophy; Cortical surface area; Disease progression; Multiple sclerosis; Quantification
International Standard Serial Number (ISSN)
Article - Journal
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01 Apr 2007