Reduced Cortical Surface Area in Multiple Sclerosis

Author

Daniel B. Hier, Missouri University of Science and TechnologyFollow
Jun Wang

Abstract

Objective: to Assess Utility of Cortical Surface Area as a Measure of Disease Progression in Multiple Sclerosis (MS). Methods: We Measured Two-Dimensional Flattened Cortical Surface Area on High-Resolution Magnetic Resonance Imaging (MRI) Scans Obtained in 15 Subjects with Clinically Definite MS and Ten Normal Subjects. Results and Discussion: Single Hemisphere Cortical Area Was Reduced in MS Patients Compared with Controls (96,451 Versus 71,710 Mm2). We Found No Significant Relationship of Cortical Surface Area to Disability or Disease Duration. T2 Lesion Load Was Negatively Correlated with Two-Dimensional Cortical Surface Area (R= -0.62). Conclusion: Cortical Surface Area is Decreased in MS and May Be a Useful Measure of Disease Progression. © 2007 W. S. Maney & Son Ltd.

Recommended Citation

D. B. Hier and J. Wang, "Reduced Cortical Surface Area in Multiple Sclerosis," Neurological Research, vol. 29, no. 3, pp. 231 - 232, Taylor and Francis Group; Taylor and Francis, Apr 2007.

The definitive version is available at https://doi.org/10.1179/174313206X154003

Department(s)

Chemistry

Keywords and Phrases

Cortical atrophy; Cortical surface area; Disease progression; Multiple sclerosis; Quantification

International Standard Serial Number (ISSN)

0161-6412

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2023 Taylor and Francis Group; Taylor and Francis, All rights reserved.

Publication Date

01 Apr 2007

PubMed ID

17509219