Stroke Due to Fungal Infections


Stroke Due to Fungal Infection is Rare. Walshe Et Al. (1985b) Reviewed the 1953-1978 Autopsy Records of the Johns Hopkins Hospital. There Were 60 Autopsied Cases with Central Nervous System (CNS) Involvement by Fungus. the Most Common Pathogens Were Aspergillus (16), Candida (27), and Cryptococcus (14). in Addition, There Were Two Cases of Mucor and One Case of Histoplasmosis. Meningeal Signs Were Common with Cryptococcus (86~) But Uncommon with Either Aspergillus or Candida (Less Than 10~). Focal Neurological Signs, Focal Seizures, Hemiplegia, and Cranial Nerve Deficits Occurred in 50~ of the Patients with Aspergillus, 21~ of Those with Cryptococcus, and 4~ of Those with Candida. Pathological Examination Showed Meningeal Inflammation in the Cases of Cryptococcus. Angioinvasion Occurred in All Cases of Aspergillus, 7~ of the Cases of Candida, and None of the Cryptococcal Cases. of the Three Most Common Fungal Pathogens, Stroke and Stroke-Like Syndromes Are Most Likely to Occur with Aspergillus, Unlikely to Occur with Candida, and Are Unreported with Cryptococcus. Not All Patients with Invasive Fungal Infection Will Have CNS Involvement. Schwesinger Et Al. (2005) Reviewed 2027 Autopsies at Greifswald University Institute of Pathology between 1994 and 2003. They Found 137 Cases of Invasive Candidiasis (6.7~) and 31 Cases of Invasive Aspergillosis (1.5~). in Only Five Cases of Candidiasis and Two Cases of Aspergillosis Was There CNS Involvement. Liu Et Al. (2003) Examined 149 Cases of Nosocomial Fungal Infections over a 20-Year Period at Peking Union Medical College Hospital.



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Publication Date

01 Jan 2008