Abstract
Polyphenols and representative small phenolic acids and molecules derived from larger constituents are dietary antioxidants from fruits, vegetables and largely other plant-based sources that have ability to scavenge free radicals. What is often neglected in polyphenol metabolism is bioavailability and the role of the gut microbiota (GMB), which has an essential role in health and disease and participates in co-metabolism with the host. The composition of the gut microbiota is in constant flux and is modified by multiple intrinsic and extrinsic factors, including antibiotics. Dietary or other factors are key modulators of the host gut milieu. In this review, we explore the role of polyphenols and select phenolic compounds as metabolic or intrinsic biochemistry regulators and explore this relationship in the context of the microbiota–gut–target organ axis in health and disease.
Recommended Citation
M. Obrenovich et al., "Polyphenols and Small Phenolic Acids as Cellular Metabolic Regulators," Current Issues in Molecular Biology, vol. 44, no. 9, pp. 4152 - 4166, MDPI, Sep 2022.
The definitive version is available at https://doi.org/10.3390/cimb44090285
Department(s)
Chemistry
Keywords and Phrases
catechins; eugenol; green tea; mass spectrometry; microbiota; polyphenols; resveratrol; small phenolic acids; whole genome sequencing
International Standard Serial Number (ISSN)
1467-3045; 1467-3037
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2023 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Sep 2022
PubMed ID
36135197
