Polyphenols and representative small phenolic acids and molecules derived from larger constituents are dietary antioxidants from fruits, vegetables and largely other plant-based sources that have ability to scavenge free radicals. What is often neglected in polyphenol metabolism is bioavailability and the role of the gut microbiota (GMB), which has an essential role in health and disease and participates in co-metabolism with the host. The composition of the gut microbiota is in constant flux and is modified by multiple intrinsic and extrinsic factors, including antibiotics. Dietary or other factors are key modulators of the host gut milieu. In this review, we explore the role of polyphenols and select phenolic compounds as metabolic or intrinsic biochemistry regulators and explore this relationship in the context of the microbiota–gut–target organ axis in health and disease.



Keywords and Phrases

catechins; eugenol; green tea; mass spectrometry; microbiota; polyphenols; resveratrol; small phenolic acids; whole genome sequencing

International Standard Serial Number (ISSN)

1467-3045; 1467-3037

Document Type

Article - Journal

Document Version

Final Version

File Type





© 2023 The Authors, All rights reserved.

Creative Commons Licensing

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Publication Date

01 Sep 2022

PubMed ID


Included in

Chemistry Commons