The Applications of Functionalized DNA Nanostructures in Bioimaging and Cancer Therapy
Deoxyribonucleic acid (DNA) is a molecular carrier of genetic information that can be fabricated into functional nanomaterials in biochemistry and engineering fields. Those DNA nanostructures, synthesized via Watson-Crick base pairing, show a wide range of attributes along with excellent applicability, precise programmability, and extremely low cytotoxicity in vitro and in vivo. In this review, the applications of functionalized DNA nanostructures in bioimaging and tumor therapy are summarized. We focused on approaches involving DNA origami nanostructures due to their widespread use in previous and current reports. Non-DNA origami nanostructures such as DNA tetrahedrons are also covered. Finally, the remaining challenges and perspectives regarding DNA nanostructures in the biomedical arena are discussed.
Y. Zeng et al., "The Applications of Functionalized DNA Nanostructures in Bioimaging and Cancer Therapy," Biomaterials, vol. 268, Elsevier, Jan 2021.
The definitive version is available at https://doi.org/10.1016/j.biomaterials.2020.120560
Keywords and Phrases
Bioimaging; Cancer Therapy; DNA Nanostructures; DNA Origami
International Standard Serial Number (ISSN)
Article - Journal
© 2021 Elsevier, All rights reserved.
01 Jan 2021
National Science Foundation, Grant CCF-1814797