Control of the Stepwise Assembly-Disassembly of DNA Origami Nanoclusters by pH Stimuli-Responsive DNA Triplexes
We present the pH-triggered reversible assembly of DNA origami clusters in a stepwise fashion. The structure formation and dissociation are controlled by a series of consecutive pH-stimulation processes that rely on the triplex-to-duplex transition of DNA triplexes in different pH conditions. This multilevel dynamic assembly strategy brings more structural complexity and provides the possibility of developing intelligent materials for engineering applications.
S. Yang et al., "Control of the Stepwise Assembly-Disassembly of DNA Origami Nanoclusters by pH Stimuli-Responsive DNA Triplexes," Nanoscale, vol. 11, no. 39, pp. 18026 - 18030, Royal Society of Chemistry, Oct 2019.
The definitive version is available at https://doi.org/10.1039/c9nr05047g
Center for Research in Energy and Environment (CREE)
Keywords and Phrases
Intelligent materials, DNA triplexes; Dynamic assembly; Engineering applications; Stepwise assembly; Stimulation process; Stimuli-responsive; Structural complexity; Structure formations, DNA, article; dissociation
International Standard Serial Number (ISSN)
Article - Journal
© 2019 Royal Society of Chemistry, All rights reserved.
01 Oct 2019
This work was supported by the National Science Foundation under grants CCF-1814797.