Title

Control of the Stepwise Assembly-Disassembly of DNA Origami Nanoclusters by pH Stimuli-Responsive DNA Triplexes

Abstract

We present the pH-triggered reversible assembly of DNA origami clusters in a stepwise fashion. The structure formation and dissociation are controlled by a series of consecutive pH-stimulation processes that rely on the triplex-to-duplex transition of DNA triplexes in different pH conditions. This multilevel dynamic assembly strategy brings more structural complexity and provides the possibility of developing intelligent materials for engineering applications.

Department(s)

Chemistry

Comments

This work was supported by the National Science Foundation under grants CCF-1814797.

Keywords and Phrases

Intelligent materials, DNA triplexes; Dynamic assembly; Engineering applications; Stepwise assembly; Stimulation process; Stimuli-responsive; Structural complexity; Structure formations, DNA, article; dissociation

International Standard Serial Number (ISSN)

2040-3364; 2040-3372

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2019 Royal Society of Chemistry, All rights reserved.

Publication Date

01 Oct 2019

PubMed ID

31560004

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