Self-Organized Architectures from Assorted DNA-Framed Nanoparticles
The science of self-assembly has undergone a radical shift from asking questions about why individual components self-organize into ordered structures, to manipulating the resultant order. However, the quest for far-reaching nanomanufacturing requires addressing an even more challenging question: how to form nanoparticle (NP) structures with designed architectures without explicitly prescribing particle positions. Here we report an assembly concept in which building instructions are embedded into NPs via DNA frames. The integration of NPs and DNA origami frames enables the fabrication of NPs with designed anisotropic and selective interactions. Using a pre-defined set of different DNA-framed NPs, we show it is possible to design diverse planar architectures, which include periodic structures and shaped meso-objects that spontaneously emerge on mixing of the different topological types of NP. Even objects of non-trivial shapes, such as a nanoscale model of Leonardo da Vinci's Vitruvian Man, can be self-assembled successfully.
W. Liu et al., "Self-Organized Architectures from Assorted DNA-Framed Nanoparticles," Nature Chemistry, vol. 8, no. 9, pp. 867 - 873, Nature Publishing Group, Sep 2016.
The definitive version is available at https://doi.org/10.1038/nchem.2540
Keywords and Phrases
DNA; gold; metal nanoparticle, anisotropy; chemistry; conformation; particle size, Anisotropy; DNA; Gold; Metal Nanoparticles; Nucleic Acid Conformation; Particle Size
International Standard Serial Number (ISSN)
Article - Journal
© 2016 Nature Publishing Group, All rights reserved.
01 Sep 2016