Self-Organized Architectures from Assorted DNA-Framed Nanoparticles

Abstract

The science of self-assembly has undergone a radical shift from asking questions about why individual components self-organize into ordered structures, to manipulating the resultant order. However, the quest for far-reaching nanomanufacturing requires addressing an even more challenging question: how to form nanoparticle (NP) structures with designed architectures without explicitly prescribing particle positions. Here we report an assembly concept in which building instructions are embedded into NPs via DNA frames. The integration of NPs and DNA origami frames enables the fabrication of NPs with designed anisotropic and selective interactions. Using a pre-defined set of different DNA-framed NPs, we show it is possible to design diverse planar architectures, which include periodic structures and shaped meso-objects that spontaneously emerge on mixing of the different topological types of NP. Even objects of non-trivial shapes, such as a nanoscale model of Leonardo da Vinci's Vitruvian Man, can be self-assembled successfully.

Department(s)

Chemistry

Keywords and Phrases

DNA; gold; metal nanoparticle, anisotropy; chemistry; conformation; particle size, Anisotropy; DNA; Gold; Metal Nanoparticles; Nucleic Acid Conformation; Particle Size

International Standard Serial Number (ISSN)

1755-4330; 1755-4349

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2016 Nature Publishing Group, All rights reserved.

Publication Date

01 Sep 2016

PubMed ID

27554413

Link to Full Text

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