A cost effective and generally applicable co-functionalization of gold nanoparticles with a mixed DNA and PEG polymers is reported. Compared to the pure DNA functionalization method, this protocol uses a much smaller amount of thiol-DNA to achieve a similar binding efficacy of gold nanoparticles with DNA origami nanostructures. The lower consumption of DNA provides a scaling-up potential for the application of DNA-nanoparticle conjugates in nanotechnology.
R. Wang et al., "Cost Effective Surface Functionalization of Gold Nanoparticles with a Mixed DNA and PEG Monolayer for Nanotechnology Applications," RSC Advances, vol. 2017, no. 7, pp. 3676-3679, Royal Society of Chemistry, Jan 2017.
The definitive version is available at https://doi.org/10.1039/C6RA26791B
Keywords and Phrases
Cost Effectiveness; Fiber Optic Sensors; Gold; Metal Nanoparticles; Nanoparticles; Nanostructures; Nanotechnology; Binding Efficacy; Dna Nanoparticles; Dna Origamis; Functionalizations; Surface Functionalization
International Standard Serial Number (ISSN)
Article - Journal
© 2017 Royal Society of Chemistry, All rights reserved.