Abstract

Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl 2] followed by [Cu(TATSC)Cl 2] and the ligand in compariosn with cisplatin.

Department(s)

Chemistry

International Standard Serial Number (ISSN)

0793-0291

Document Type

Article - Journal

Document Version

Final Version

File Type

text

Language(s)

English

Rights

© 1999 Hindawi Publishing Corporation, All rights reserved.

Included in

Chemistry Commons

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