Metal Complexes as Anticancer Agents 2
Synthesis, spectroscopy, magnetism, electrochemistry, X-ray crystal structure and antimelanomal activity of the copper (II) complex of 5-amino-1-tolylimidazole-4-carboxylate in B16F10 mouse melanoma cells
The copper complex [Cu(ATICAR)2(H2O)]·2H2O (ATICAR = 5-amino-1-tolylimidazole-4-carboxylate) has been prepared and characterized by its crystal structure determination. The ligand geometry around the copper(II) center is best described as predominantly square pyramidal (2/3) with a trigonal bipyramidal component (1/3). The ATICAR ligands act as bidentates to form the distorted square pyramid base of N2O2 donor atoms and a coordinated water molecule at the apex is held with a Cu-O bond that is unusually short (2.148 A) for square pyramidal copper(II). Compound exhibits a dose-dependent antiproliferative effect on the growth of the B16F10 melanoma cell line while its lower IC50 value establish advantage by copper complexation. (C) 2000 Elsevier Science S.A.
M. Collins et al., "Metal Complexes as Anticancer Agents 2," Inorganic Chemistry Communications, Elsevier, Jan 2000.
The definitive version is available at http://dx.doi.org/10.1016/S1387-7003(00)00108-8
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