Effect of Flow on Mass Transfer in Drug Delivery
Drug delivery is usually considered using a stirred tank model, which does not include all the mass transfer resistances. A distributed system called Krogh cylinder has been used here. The complex capillary network is broken down into cylindrical cells, each containing a capillary and appropriate amount of extravascular tissue. The flow has two-dimensional velocities, which are in the axial and the radial directions. Most of the drug uptake happens through convection, which is slowed down in the presence of a reaction. Local equilibrium is assumed, which cuts down the computations and provides good results for the case of reactive solutes. The results of a distributed system have been obtained for the first time, and mechanics of how area-under-the-curve can be used to calculate the actual solute uptake is illustrated. The results emphasize the need for a higher rate of perfusion in the tumor because of the importance of convection.
X. Qiu and P. Neogi, "Effect of Flow on Mass Transfer in Drug Delivery," Proceedings of the 2020 AIChE Virtual Annual Meeting, American Institute of Chemical Engineers (AIChE), Nov 2020.
2020 AIChE Annual Meeting (2020: Nov. 16-20, Virtual)
Chemical and Biochemical Engineering
Keywords and Phrases
Convective-diffusive transport; Drug delivery; Krogh cylinder
International Standard Book Number (ISBN)
Article - Conference proceedings
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20 Nov 2020