Title

Effect of Flow on Mass Transfer in Drug Delivery

Abstract

Drug delivery is usually considered using a stirred tank model, which does not include all the mass transfer resistances. A distributed system called Krogh cylinder has been used here. The complex capillary network is broken down into cylindrical cells, each containing a capillary and appropriate amount of extravascular tissue. The flow has two-dimensional velocities, which are in the axial and the radial directions. Most of the drug uptake happens through convection, which is slowed down in the presence of a reaction. Local equilibrium is assumed, which cuts down the computations and provides good results for the case of reactive solutes. The results of a distributed system have been obtained for the first time, and mechanics of how area-under-the-curve can be used to calculate the actual solute uptake is illustrated. The results emphasize the need for a higher rate of perfusion in the tumor because of the importance of convection.

Meeting Name

2020 AIChE Annual Meeting (2020: Nov. 16-20, Virtual)

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

Convective-diffusive transport; Drug delivery; Krogh cylinder

International Standard Book Number (ISBN)

978-081691114-1

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2021 American Institute of Chemical Engineers (AIChE), All rights reserved.

Publication Date

20 Nov 2020

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