Title

Synthesis and Characterization of a Novel Dendrimer-Based Thermoresponsive Core-Shell Nanoparticle for Drug Delivery

Abstract

This study describes a novel thermoresponsive dendritic polyethylene glycol-poly(D, L-lactide) (PEG-PDLLA) core-shell nanoparticle with potential for drug delivery and controlled release. Dendritic PEG-PDLLA in aqueous phase could self-assemble into spherical aggregates and the size of spherical aggregates increased with PEG chain length increase. Further, spherical aggregates made of dendritic PEG-PDLLA exhibited magnified temperature- dependence in terms of solubility change and dimension expansion as compared to linear PEG-PDLLA. The most significant size expansion was observed in particles made of dendritic PEG (12000)-PDLLA, which was twice as much as that of particles made of linear PEG (12000)-PDLLA. Water insoluble antitumor drug camptothecin (CPT) was used as a model drug for encapsulation and release studies. Spherical aggregates encapsulated more CPT when dendritic PEG-PDLLA had longer PEG-PDLLA chain and/or when temperature was elevated to body temperature. This study demonstrated that nanoscale clustering PEG-PDLLA through dendrimers magnified the thermo-sensitivity of PEG-PELLA. Successful development of such a new particulate system made of dendritic PEG-PDLLA with an expandable dimension in response to temperature change generated a new direction for designing stimuli-responsive materials.

Meeting Name

2008 MRS Spring Meeting (2008: Mar. 24-28, San Francisco, CA)

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

Antitumor drugs; Aqueous phase; Body temperature; Camptothecins; Controlled release; Core-shell nanoparticles; Model drugs; Nano scale; New directions; Particulate systems; Poly (D ,L-lactide); Self-assemble; Spherical aggregates; Stimuli-responsive materials; Synthesis and characterization; Temperature changes; Temperature dependence; Thermo-responsive; Thermosensitivities, Aggregates; Biological materials; Biomaterials; Charge trapping; Controlled drug delivery; Dendrimers; Nanoparticles; Polyethylene oxides; Polymer blends; Spheres; Thermal effects, Polyethylene glycols

International Standard Book Number (ISBN)

978-160560849-5

International Standard Serial Number (ISSN)

1946-4274

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2008 Materials Research Society (MRS), All rights reserved.

Publication Date

28 Mar 2008

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