Poly(Ethylene Glycol)-Armed Hyperbranched Polyoxetanes for Anticancer Drug Delivery


A facile method for synthesis of poly ethylene glycol (PEG)-armed hyperbranched polyoxetanes is presented along with characterization and use in drug delivery. A series of hyperbranched polyoxetanes with multiple PEG arms were synthesized via a one-pot cationic ring-opening polymerization of 3-ethyl-3-hydroxymethyl oxetane (EHMO) and its PEGylated derivative (EPMO), in which the feed mass ratio of EHMO to EPMO was 98:2, 96:4, 74:26, or 17:83. Characterization methods included nuclear magnetic resonance, dynamic light scattering, Fourier transform infrared, differential scanning calorimetry, and scanning electron microscopy. Toxicity of the synthesized polymers to human dermal fibroblasts was evaluated using the MTT assay. Formulation into particles was carried out to encapsulate the anticancer drug camptothecin using the single oil-in-water solvent evaporation method. The resulting drug encapsulated particles were evaluated for antitumor activity using HN12 cells.


Chemical and Biochemical Engineering


This study was supported, in part, by the National Science Foundation (CAREER award CBET0954957) and Jeffress Memorial Trust (J-1043) (HY) and the National Science Foundation (DMR0207560 and DMR0802452) (KJW).

Keywords and Phrases

Anticancer drug delivery; hyperbranched polymer; PEGylation; polyether polyol

International Standard Serial Number (ISSN)

0883-9115; 1530-8030

Document Type

Article - Journal

Document Version


File Type





© 2012 The Authors, All rights reserved.

Publication Date

01 Nov 2012