Nanoparticle-Mediated Brain-Specific Drug Delivery, Imaging, and Diagnosis
Central nervous system (CNS) diseases represent the largest and fastest-growing area of unmet medical need. Nanotechnology plays a unique instrumental role in the revolutionary development of brain-specific drug delivery, imaging, and diagnosis. With the aid of nanoparticles of high specificity and multifunctionality, such as dendrimers and quantum dots, therapeutics, imaging agents, and diagnostic molecules can be delivered to the brain across the blood-brain barrier (BBB), enabling considerable progress in the understanding, diagnosis, and treatment of CNS diseases. Nanoparticles used in the CNS for drug delivery, imaging, and diagnosis are reviewed, as well as their administration routes, toxicity, and routes to cross the BBB. Future directions and major challenges are outlined.
H. Yang, "Nanoparticle-Mediated Brain-Specific Drug Delivery, Imaging, and Diagnosis," Pharmaceutical Research, vol. 27, no. 9, pp. 1759 - 1771, Springer Science+Business Media, LLC, Sep 2010.
The definitive version is available at https://doi.org/10.1007/s11095-010-0141-7
Chemical and Biochemical Engineering
Keywords and Phrases
BBB; diagnosis; drug delivery; imaging; nanoparticles
International Standard Serial Number (ISSN)
Article - Journal
© 2010 Springer Science+Business Media, LLC, All rights reserved.
01 Sep 2010
This work was supported by National Institutes of Health (R21NS063200).