Micro-Channel Diffusion Characteristics of an Implantable Drug Delivery Device for Age-Related Macular Degeneration
There is an increasing need to develop implantable drug delivery devices for effective therapeutic management of chronic ocular diseases such as age-related macular degeneration (AMD). In this work, we designed four different micro-channel configurations for an implantable device and elucidate drug diffusion characteristics using both simulation and experimental measurements. Our simulation and experimental results show that three micro-channel configurations are capable of sustaining drug release and can be incorporated into an implantable device to exert long-term drug release required for therapeutic management of AMD.
R. M. Pidaparti et al., "Micro-Channel Diffusion Characteristics of an Implantable Drug Delivery Device for Age-Related Macular Degeneration," Microsystem Technologies, vol. 21, no. 9, pp. 1967-1974, Springer Verlag, Sep 2015.
The definitive version is available at https://doi.org/10.1007/s00542-014-2307-4
Chemical and Biochemical Engineering
Keywords and Phrases
Implants (surgical), Age-related macular degeneration; Diffusion characteristics; Drug diffusion; Drug release; Implantable devices; Implantable drug delivery; Ocular disease, Ophthalmology
International Standard Serial Number (ISSN)
Article - Journal
© 2015 Springer Verlag, All rights reserved.
21 Sep 2015