Micro-Channel Diffusion Characteristics of an Implantable Drug Delivery Device for Age-Related Macular Degeneration

Abstract

There is an increasing need to develop implantable drug delivery devices for effective therapeutic management of chronic ocular diseases such as age-related macular degeneration (AMD). In this work, we designed four different micro-channel configurations for an implantable device and elucidate drug diffusion characteristics using both simulation and experimental measurements. Our simulation and experimental results show that three micro-channel configurations are capable of sustaining drug release and can be incorporated into an implantable device to exert long-term drug release required for therapeutic management of AMD.

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

Implants (surgical), Age-related macular degeneration; Diffusion characteristics; Drug diffusion; Drug release; Implantable devices; Implantable drug delivery; Ocular disease, Ophthalmology

International Standard Serial Number (ISSN)

0946-7076; 1432-1858

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2015 Springer Verlag, All rights reserved.

Publication Date

21 Sep 2015

Link to Full Text

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