Title

Drug-Conjugated Dendrimer Hydrogel Enables Sustained Drug Release Via a Self-Cleaving Mechanism

Abstract

In this study, the anticancer drug, camptothecin (CPT), was covalently grafted onto polyamidoamine (PAMAM) dendrimer surface and then reacted with polyethylene glycol diacrylate (PEG-DA) to form dendrimer hydrogel (DH-G3-CPT) with low cross-linking density. In this novel drug delivery system, CPT was cleaved from dendrimer via the ammonolysis of ester bonds and then diffused out of the hydrogel network, thus leading to significantly prolonged drug release. The self-cleaving release kinetics of camptothecin can be further tuned by pH. This DH-G3-CPT drug delivery system has both injectability and sustained drug release. It showed an excellent tumor inhibition effect following intratumoral injection in a head and neck cancer model of mouse.

Department(s)

Chemical and Biochemical Engineering

Comments

This work was supported, in part, by the National Institutes of Health (R01EY024072).

Keywords and Phrases

camptothecin; dendrimer; drug delivery; hydrogel; self-cleaving

International Standard Serial Number (ISSN)

1543-8384; 1543-8392

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2019 American Chemical Society (ACS), All rights reserved.

Publication Date

06 May 2019

PubMed ID

30974947

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