Engineering Porous Polymer Hollow Fiber Microfluidic Reactors for Sustainable C-H Functionalization


Highly hydrophilic and solvent-stable porous polyamide-imide (PAI) hollow fibers were created by cross-linking of bare PAI hollow fibers with 3-aminopropyl trimethoxysilane (APS). The APS-grafted PAI hollow fibers were then functionalized with salicylic aldehyde for binding catalytically active Pd(II) ions through a covalent postmodification method. The catalytic activity of the composite hollow fiber microfluidic reactors (Pd(II) immobilized APS-grafted PAI hollow fibers) was tested via heterogeneous Heck coupling reaction of aryl halides under both batch and continuous-flow reactions in polar aprotic solvents at high temperature (120°C) and low operating pressure. X-ray photoelectron spectroscopy (XPS) and inductively coupled plasma (ICP) analyses of the starting and recycled composite hollow fibers indicated that the fibers contain very similar loadings of Pd(II), implying no degree of catalyst leaching from the hollow fibers during reaction. The composite hollow fiber microfluidic reactors showed long-term stability and strong control over the leaching of Pd species.


Chemical and Biochemical Engineering

Second Department


Keywords and Phrases

Batch Reactors; Catalyst Activity; Catalysts; Chemical Reactions; Grafting (Chemical); Inductively Coupled Plasma; Leaching; Microfluidics; Palladium Compounds; Polyamideimides; X Ray Photoelectron Spectroscopy; 3-Aminopropyl Trimethoxysilane; Composite Hollow Fibers; Continuous Flow Reaction; Heck Coupling; Heck Coupling Reaction; Heterogeneous Catalyst; Inductively Coupled Plasma Analysis; Micro-Fluidic Reactors; Fibers; Hollow Fiber Microfluidic Reactors; Immobilized Pd(II) Ions; Polyamide-Imide

International Standard Serial Number (ISSN)

1944-8244; 1944-8252

Document Type

Article - Journal

Document Version


File Type





© 2017 American Chemical Society (ACS), All rights reserved.

Publication Date

01 May 2017

PubMed ID