Advanced Hydrogel Formulations for the Eye
Abstract
Several novel types of ocular hydrogel formulations have been developed to address safety and ease of application. This chapter discusses supramolecular hydrogels and dendrimer hydrogels. Mechanisms underlying the formation of those hydrogels and their applications for medication of ocular diseases are reviewed. Supramolecular hydrogels form on the basis of host-guest interactions. Dendrimer hydrogels are comprised of well-defined hyperbranched dendrimer building blocks. Green chemistry including the aza-Michael addition and biorthogonal chemistry have been successfully applied to make dendrimer hydrogels. These new formulations hold promise for improving ocular disease treatment but require further assessment in pre-clinical and clinical studies for bench-to-bedside translation.
Recommended Citation
H. Yang, "Advanced Hydrogel Formulations for the Eye," AAPS Advances in the Pharmaceutical Sciences Series, vol. 37, pp. 449 - 462, Springer, Jan 2021.
The definitive version is available at https://doi.org/10.1007/978-3-030-76367-1_16
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Aza-Michael addition; Biorthogonal chemistry; Dendrimer hydrogel; Glaucoma; Green chemistry; Host-guest interactions; Ocular drug delivery; Supramolecular hydrogel
International Standard Serial Number (ISSN)
2210-738X; 2210-7371
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Springer, All rights reserved.
Publication Date
01 Jan 2021
Comments
National Institutes of Health, Grant R01EY024072