The Bioactivity and Ion Release of Titanium-Containing Glass Polyalkenoate Cements for Medical Applications
The ion release profiles and bioactivity of a series of Ti containing glass polyalkenoate cements. Characterization revealed each material to be amorphous with a Tg in the region of 650-660°C. The network connectivity decreased (1.83-1.35) with the addition of TiO2 which was also evident with analysis by X-ray photoelectron spectroscopy. Ion release from cements were determined using atomic absorption spectroscopy for zinc (Zn2+), calcium (Ca2+), strontium (Sr2+), Silica (Si4+) and titanium (Ti4+). Ions such as Zn2+ (0.1-2.0 mg/l), Ca2+ (2.0-8.3 mg/l,) Sr2+ (0.1-3.9 mg/l), and Si4+ (14-90 mg/l) were tested over 1-30 days. No Ti4+ release was detected. Simulated body fluid revealed a CaP surface layer on each cement while cell culture testing of cement liquid extracts with TW-Z (5 mol% TiO2) produced the highest cell viability (161%) after 30 days. Direct contact testing of discs resulted in a decrease in cell viability of the each cement tested. © 2010 Springer Science+Business Media, LLC.
A. W. Wren et al., "The Bioactivity and Ion Release of Titanium-Containing Glass Polyalkenoate Cements for Medical Applications," Journal of Materials Science: Materials in Medicine, vol. 22, no. 1, pp. 19 - 28, Springer, Jan 2011.
The definitive version is available at https://doi.org/10.1007/s10856-010-4184-4
Chemical and Biochemical Engineering
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01 Jan 2011
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