An off-the-shelf Raman Spectrometer (RS) was used to noninvasively determine the presence of monosodium urate (MSU) crystals on the metatarsophalangeal joint (MTPJ) of a single gout sufferer. The spectrum sourced from the clinically diagnosed gout sufferer was compared to that sourced from an age-matched healthy subject scanned using the same protocol. Minimal signal processing was conducted on both spectra. Peaks characteristic of MSU crystals were evident on the spectrum sourced from the gout sufferer and not on the spectrum from the healthy control.
D. J. Curran et al., "Raman Spectroscopy Applied to the Noninvasive Detection of Monosodium Urate Crystal Deposits," Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, vol. 8, pp. 55 - 58, SAGE Publications, Aug 2015.
The definitive version is available at https://doi.org/10.4137/CMAMD.S29061
Chemical and Biochemical Engineering
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18 Aug 2015