Title

Evolutionary Timeline of Genetic Delivery and Gene Therapy

Abstract

There are more than 3,500 genes that are being linked to hereditary diseases or correlated with an elevated risk of certain illnesses. As an alternative to conventional treatments with small molecule drugs, gene therapy has arisen as an effective treatment with the potential to not just alleviate disease conditions but also cure them completely. In order for these treatment regimens to work, genes or editing tools intended to correct diseased genetic material must be efficiently delivered to target sites. There have been many techniques developed to achieve such a goal. In this article, we systematically review a variety of gene delivery and therapy methods that include physical methods, chemical and biochemical methods, viral methods, and genome editing. We discuss their historical discovery, mechanisms, advantages, limitations, safety, and perspectives.

Department(s)

Biological Sciences

Keywords and Phrases

CPPs; CRISPR; Gene Therapy; Genetic Delivery; Genome Editing; Nonviral; TALENs; Viral; ZFNs

International Standard Serial Number (ISSN)

1875-5631

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2021 Bentham Science Publishers, All rights reserved.

Publication Date

01 Feb 2021

PubMed ID

33292120

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