Bioactive glasses have recently gained attention in tissue engineering and three-dimensional (3D) bioprinting because of their ability to enhance angiogenesis. Some challenges for developing biological tissues with bioactive glasses include incorporation of glass particles and achieving a 3D architecture mimicking natural tissues. In this study, we investigate the fabrication of scaffolds with a polymer/bioactive glass composite using near-field electrospinning (NFES). An overall controlled 3D scaffold with pores, containing random fibers, is created and aimed to provide superior cell proliferation. Highly angiogenic borate bioactive glass (13-93B3) in 20 wt.% is added to polycaprolactone (PCL) to fabricate scaffolds using the NFES technique. Scaffolds measuring 5 mm x 5 mm x 0.2 mm 3 in overall dimensions were seeded with human adipose-derived mesenchymal stem cells to investigate the cell viability. The cell viability on PCL and PCL+glass scaffolds fabricated using NFES technique and 3D printing is compared and discussed. The results indicated higher cell proliferation on 3D biomimetic scaffolds fabricated by NFES technique.
K. C. Kolan et al., "Near-Field Electrospinning of a Polymer/Bioactive Glass Composite to Fabricate 3D Biomimetic Structures," International Journal of Bioprinting, vol. 5, no. 1, Whioce Publishing Pte. Ltd., Jan 2019.
The definitive version is available at https://doi.org/10.18063/ijb.v5i1.163
Mechanical and Aerospace Engineering
Materials Science and Engineering
Keywords and Phrases
Borate bioactive glass; Human adipose-derived stem cells; Near-field electrospinning; Polycaprolactone; Polymer/bioactive glass composite; Three-dimensional biomimetic scaffold
International Standard Serial Number (ISSN)
Article - Journal
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