Nanotechnology has evolved to play a prominent role in our economy. Increased use of nanomaterials poses potential human health risk. It is therefore critical to understand the nature and origin of the toxicity imposed by nanomaterials (nanotoxicity). In this article we review the toxicity of the transition metal oxides in the 4th period that are widely used in industry and biotechnology. Nanoparticle toxicity is compellingly related to oxidative stress and alteration of calcium homeostasis, gene expression, pro-inflammatory responses, and cellular signaling events. The precise physicochemical properties that dictate the toxicity of nanoparticles have yet to be defined, but may include element-specific surface catalytic activity (e.g., metallic, semiconducting properties), nanoparticle uptake, or nanoparticle dissolution. These in vitro studies substantially advance our understanding in mechanisms of toxicity, which may lead to safer design of nanomaterials.
Y. Huang et al., "Toxicity of Transition Metal Oxide Nanoparticles: Recent Insights from in vitro Studies," Materials, vol. 3, no. 10, pp. 4842 - 4859, MDPI, Oct 2010.
The definitive version is available at https://doi.org/10.3390/ma3104842
Keywords and Phrases
Calcium Homeostasis; Metal Oxides; Nanoparticle Toxicity; Physicochemical Property; Semi-Conducting Property; Surface Catalytic Activity; Transition Metal Oxide Nanoparticles; Transition-Metal Oxides; Calcium; Gene Expression; Nanoparticles; Nanostructured Materials; Oxidative Stress; Physiology; Signal Transduction; Toxicity
International Standard Serial Number (ISSN)
Article - Journal
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01 Oct 2010