Many viral and nonviral systems have been developed to aid delivery of biologically active molecules into cells. Among these, cell-penetrating peptides (CPPs) have received increasing attention in the past two decades for biomedical applications. In this review, we focus on opportunities and challenges associated with CPP delivery of nucleic acids and nanomaterials. We first describe the nature of versatile CPPs and their interactions with various types of cargoes. We then discuss in vivo and in vitro delivery of nucleic acids and nanomaterials by CPPs. Studies on the mechanisms of cellular entry and limitations in the methods used are detailed.
Y. Huang et al., "Delivery of Nucleic Acids and Nanomaterials by Cell-Penetrating Peptides: Opportunities and Challenges," BioMed Research International, vol. 2015, Hindawi Publishing Corporation, Sep 2015.
The definitive version is available at https://doi.org/10.1155/2015/834079
Keywords and Phrases
Nanomaterial; Penetratin; Polyarginine; Protein VP22; Small Interfering RNA; Amino Acid Sequence; Gene Delivery System; Gene Targeting; In Vitro Study; In Vivo Study; Synthesis; Procedures; Animals; Cell-Penetrating Peptides; Drug Delivery Systems; Humans; Nanostructures; Nucleic Acids
International Standard Serial Number (ISSN)
Article - Journal
© 2015 The Authors, All rights reserved.
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01 Sep 2015