Three-dimensional (3D) bioprinting is an emerging technology in which scaffolding materials and cell-laden hydrogels may be deposited in a pre-determined fashion to create 3D porous constructs. A major challenge in 3D bioprinting is the slow degradation of melt deposited biopolymer. In this paper, we describe a new method for printing poly-caprolactone (PCL)/bioactive borate glass composite as a scaffolding material and Pluronic F127 hydrogel as a cell suspension medium. Bioactive borate glass was added to a mixture of PCL and organic solvent to make an extrudable paste using one syringe while hydrogel was extruded and deposited in between the PCL/borate glass filaments using a second syringe. The degradation of the PCL/borate glass composite scaffold with and without the presence of hydrogel was investigated by soaking the scaffold in minimum essential medium. The weight loss of the scaffold together with formation of a hydroxyapatite-like layer on the surface shows the excellent bioactivity of the scaffold.
K. Kolan et al., "Solvent Based 3D Printing of Biopolymer/Bioactive Glass Composite and Hydrogel for Tissue Engineering Applications," Procedia CIRP, vol. 65, pp. 38 - 43, Elsevier B.V., Jul 2017.
The definitive version is available at https://doi.org/10.1016/j.procir.2017.04.022
3rd CIRP Conference on BioManufacturing 2017 (2017: Jul. 11-14, Chicago, IL)
Materials Science and Engineering
Mechanical and Aerospace Engineering
Keywords and Phrases
3D Bioprinting; Biopolymer/bioactive glass composite; Borate bioactive glass; Pluronic hydrogel
International Standard Serial Number (ISSN)
Article - Conference proceedings
© 2017 Elsevier B.V., All rights reserved.
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01 Jul 2017