Power Combos: Antibody Conjugated Drug Nanorods and T Cell Therapy for Breast Cancer Treatment
Department
Chemical and Biochemical Engineering
Major
Chemical Engineering
Research Advisor
Barua, Sutapa
Advisor's Department
Chemical and Biochemical Engineering
Abstract
The purpose of this proposal is to explore a complementary combination of two promising treatments of breast cancer. Nanoparticles are appearing as an increasingly favorable approach for non-invasive and targeted delivery of therapeutic agents to breast tumor tissues. However, there are significant challenges in the delivery of nanoparticles to the target tissue. Another exploratory approach to breast cancer treatment is to activate a patient’s own immune system to attack the tumor. Specialized cells known as T cells have been shown in some cases to recognize tumor antigen and initiate systemic immune responses in the body that destroy tumor cells. While this approach shows promise, it often lacks the potency necessary for complete treatment. I want to explore a combined approach that utilizes the direction of a patient’s T-cells as well as the potency of nanoparticles of trastuzumab-conjugated camptothecin by anchoring the nanoparticles to the surface of the T-cells.
Biography
James Schuchard is an active scholar as well as an involved and impactful member of the Missouri S&T student culture. He excels academically and has been awarded the Excellence, Curators, and University scholarships by his school and the James Johnson Scholarship by the Chemical Engineering department. He contributes to the department as a Peer Learning Assistant and grader for Materials and Energy Balances. He serves Missouri S&T through involvement in Christian Campus Fellowship and Kappa Kappa Psi honorary band fraternity in which he served as Service Committee Chair.
Research Category
Engineering
Presentation Type
Poster Presentation
Document Type
Poster
Location
Upper Atrium/Hall
Presentation Date
11 Apr 2017, 1:00 pm - 3:00 pm
Power Combos: Antibody Conjugated Drug Nanorods and T Cell Therapy for Breast Cancer Treatment
Upper Atrium/Hall
The purpose of this proposal is to explore a complementary combination of two promising treatments of breast cancer. Nanoparticles are appearing as an increasingly favorable approach for non-invasive and targeted delivery of therapeutic agents to breast tumor tissues. However, there are significant challenges in the delivery of nanoparticles to the target tissue. Another exploratory approach to breast cancer treatment is to activate a patient’s own immune system to attack the tumor. Specialized cells known as T cells have been shown in some cases to recognize tumor antigen and initiate systemic immune responses in the body that destroy tumor cells. While this approach shows promise, it often lacks the potency necessary for complete treatment. I want to explore a combined approach that utilizes the direction of a patient’s T-cells as well as the potency of nanoparticles of trastuzumab-conjugated camptothecin by anchoring the nanoparticles to the surface of the T-cells.
