Evaluation of an Injectable Bioactive Borate Glass Cement to Heal Bone Defects in a Rabbit Femoral Condyle Model
There is a need for synthetic biomaterials to heal bone defects using minimal invasive surgery. In the present study, an injectable cement composed of bioactive borate glass particles and a chitosan bonding solution was developed and evaluated for its capacity to heal bone defects in a rabbit femoral condyle model. The injectability and setting time of the cement in vitro decreased but the compressive strength increased (8 ± 2 MPa to 31 ± 2 MPa) as the ratio of glass particles to chitosan solution increased (from 1.0 g ml- 1 to 2.5 g ml- 1). Upon immersing the cement in phosphate-buffered saline, the glass particles reacted and converted to hydroxyapatite, imparting bioactivity to the cement. Osteoblastic MC3T3-E1 cells showed enhanced proliferation and alkaline phosphatase activity when incubated in media containing the soluble ionic product of the cement. The bioactive glass cement showed a better capacity to stimulate bone formation in rabbit femoral condyle defects at 12 weeks postimplantation when compared to a commercial calcium sulfate cement. The injectable bioactive borate glass cement developed in this study could provide a promising biomaterial to heal bone defects by minimal invasive surgery.
X. Cui and W. Huang and Y. Zhang and C. Huang and Z. Yu and L. Wang and W. Liu and T. Wang and J. Zhou and H. Wang and N. Zhou and D. Wang and H. Pan and M. N. Rahaman, "Evaluation of an Injectable Bioactive Borate Glass Cement to Heal Bone Defects in a Rabbit Femoral Condyle Model," Materials Science and Engineering C, vol. 73, pp. 585-595, Elsevier Ltd, Apr 2017.
The definitive version is available at http://dx.doi.org/10.1016/j.msec.2016.12.101
Materials Science and Engineering
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