Keywords and Phrases
"Cytokinesis is an important step to finish cell cycle events and separate into two daughter cells. This event is driven by actomyosin ring contraction. In budding yeast, the mitotic exit network (MEN) controls completion of ana/telophase by signaling events. Bub2 is a mitotic exit network regulator and binds to Tem1p which is an important component in MEN. Mad2 is a component of a separate spindle checkpoint. Mad2 dependent pathway prevents the metaphase to anaphase transition under spindle damage. Because yeast cells have cell walls, septum formation follows actin ring contraction. Here it was investigated how microtubule defects affect cytokinesis in budding yeast. It was examined various mutant cells. Data shows that, bub2 deletion or overexpression leads to a higher rate of myosin contraction. Moreover, these mutants showed chain morphology after depolymerizaion of microtubules by nocodazole. This phenomenon is caused by cell septation defects not cell cytokinesis defects"--Abstract, page iii.
Mormile, Melanie R.
M.S. in Applied and Environmental Biology
Missouri University of Science and Technology
viii, 41 pages
© 2008 Su Young Park, All rights reserved.
Thesis - Open Access
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Link to Catalog Record
Park, Su Young, "Role of microtubules in budding yeast cytokinesis" (2008). Masters Theses. 4641.