Synthesis of the Abc Ring System of Azaspiracid. 2. a Systematic Study into the Effect of C16 and C17 Substitution on Bis-Spirocyclization

Author

Rich G. Carter
David E. Graves
Melissa A. Gronemeyer
Gregory S. Tschumper, Missouri University of Science and TechnologyFollow

Abstract

(matrix presented) A systematic study into the effect of C16 and C17 substitution on the stereochemical outcome of bis-Spiro cyclization to form the ABC ring system of azaspiracid is disclosed. Successful construction of the natural 10R,13R bis-spirocyclic stereochemistry has been accomplished on the C16 benzyloxy-containing precursor.

Recommended Citation

R. G. Carter et al., "Synthesis of the Abc Ring System of Azaspiracid. 2. a Systematic Study into the Effect of C16 and C17 Substitution on Bis-Spirocyclization," Organic Letters, vol. 4, no. 13, pp. 2181 - 2184, American Chemical Society, Jun 2002.

The definitive version is available at https://doi.org/10.1021/ol026034o

Department(s)

Chemistry

Comments

National Institute of General Medical Sciences, Grant R01GM063723

International Standard Serial Number (ISSN)

1523-7060

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 American Chemical Society, All rights reserved.

Publication Date

27 Jun 2002

PubMed ID

12074662