Title

Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

Abstract

We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. the product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

Department(s)

Chemistry

Keywords and Phrases

Catenane; DNA Hybrid; Oligonucleotide; Denaturation; DNA Cleavage; DNA Helix; DNA Strand; DNA Structure; DNA Template; Stereoisomerism; Synthesis; Anthracenes; DNA; Molecular Structure; Nucleic Acid Conformation; Oligonucleotides; Stereoisomerism; Ultraviolet Rays

International Standard Serial Number (ISSN)

0002-7863

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2008 American Chemical Society (ACS), All rights reserved.

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