Regioselectivity in Metallation Reactions of 2-(2′-naphthyl)pyridine: 1′-versus 3′-reactivity in Mercuration and Palladation Reactions
Crystal structure of chloro(pyridine) [2-(2-pyridiny)naphthyl-C3,N]palladium
Regioselectivity is found to vary with the reagent in cyclometallation reactions of 2-(2′-naphthyl)pyridine. Mercuration produces a mixture of 1′- and 3′-naphthyl metallated species with the 1′-substituted material as the major product. Palladation results in clean 3′-naphthyl metallation, as confirmed by the crystal structure of the pyridine derivative chloro(pyridine)[2-(2′-pyridinyl)naphtyl-C3, N]palladium. © 1995.
A. R. Ford et al., "Regioselectivity in Metallation Reactions of 2-(2′-naphthyl)pyridine: 1′-versus 3′-reactivity in Mercuration and Palladation Reactions," Journal of Organometallic Chemistry, Elsevier, Jan 1995.
The definitive version is available at https://doi.org/10.1016/0022-328X(94)05367-K
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