Peterson (Silyl-Wittig) Methylenation of Carbonyl Compounds Using Nafion-H® Catalyzed Hydroxy-trimethylsilane Elimination of Β-hydroxysilanes
The Peterson (silyl-Wittig) methylenation of carbonyl compounds is significantly improved by convenient hydroxy-trimethylsilane elimination of the intermediate ß-hydroxysilanes using perfluoroalkanesulfonic acid (Nafion-H®) catalysis. These high yield reactions proceed at room temperature, and the workup involves only filtration of the catalyst.
G. A. Olah et al., "Peterson (Silyl-Wittig) Methylenation of Carbonyl Compounds Using Nafion-H® Catalyzed Hydroxy-trimethylsilane Elimination of Β-hydroxysilanes," Synthesis, no. 1, pp. 29-30, Georg Thieme Verlag, Jan 1991.
The definitive version is available at http://dx.doi.org/10.1055/s-1991-26371
Keywords and Phrases
organic compound; silane derivative; reaction analysis; synthesis
International Standard Serial Number (ISSN)
Article - Journal
© 1991 Georg Thieme Verlag, All rights reserved.