Lyophilization in Vials on Trays: Effects of Tray Side
The effects of tray side on the performance of lyophilization of pharmaceuticals in vials arranged in clusters of hexagonal arrays on trays are studied and the results of this work indicate that it would be beneficial to operate the freeze drying process by employing freeze dryers whose trays have no tray sides and using heat input control that runs the lyophilization process close to the melting and scorch temperature constraints during the primary and secondary drying stages, respectively.
K. H. Gan et al., "Lyophilization in Vials on Trays: Effects of Tray Side," Drying Technology, Taylor & Francis, Jan 2005.
The definitive version is available at http://dx.doi.org/10.1081/DRT-200047671
Chemical and Biochemical Engineering
Keywords and Phrases
Distribution of Concentration of Bound Water; Distribution of Temperature; Drying Times; Freeze Drying in Vials; Heating Policies; Height of Tray Side; Hexagonal Arrays of Vials; Lyophilization in Vials; Velocity of Moving Sublimation Interface
Article - Journal
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