Abstract
Drug Repurposing Uses Approved Drugs as Candidate Anticancer Therapeutics, Harnesses Previous Research and Development Efforts, and Benefits from Available Clinically Suitable Formulations and Evidence of Patient Tolerability. in This Work, the Drug Used Clinically to Treat Chronic Alcoholism, Disulfiram (DSF), Was Studied for its Antitumor Efficacy in a Copper-Dependent Manner. the Combination of DSF and Copper Could Achieve a Tumor Cell Growth Inhibition Effect Comparable to Those of 5-Fluorouracil and Taxol on Head and Neck Cancer Cells. Both Bulk Dendrimer Hydrogel and Microsized Dendrimer Hydrogel Particles Were Utilized for the Localized Sustained Release of Copper in the Tumor Site. the Localized Sustained Release of Copper Facilitated the Tumor Inhibition Effect Following Intratumoral Injection in a Mouse's Head and Neck Cancer Model.
Recommended Citation
J. Wang et al., "Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer," Biomacromolecules, vol. 25, no. 5, pp. 2770 - 2779, American Chemical Society, May 2024.
The definitive version is available at https://doi.org/10.1021/acs.biomac.3c01420
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
1526-4602; 1525-7797
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 American Chemical Society, All rights reserved.
Publication Date
13 May 2024
PubMed ID
38687975
Comments
Natural Science Foundation of Sichuan Province, Grant 2023MSFSC1000