Abstract
A mathematical model of multi-component dynamic adsorption in columns with spherical perfusive and spherical purely diffusive adsorbent particles with a bidisperse porous structure is constructed, solved, and used to study the performance of a binary adsorption system in a single-column fixed-bed process and in a two-column periodic countercurrent process in which the adsorbent is equally distributed over two beds. The total length of the two-column periodic counter-current system is equal to the length of the single-column fixed-bed system. The performance of fixed-bed and periodic counter-current systems with both perfusive and purely diffusive adsorbent particles is examined for different values of the macropore void fraction, ε(p), the particle diameter, d(p), the inlet concentration of the least preferentially adsorbed component 2, C(d2,in), and the superficial velocity, V(f). For the binary adsorption system studied in this work, the results show that the adsorption column must be operated in the periodic counter-current mode at low values of the superficial velocity, V(f), in order to achieve high relative separation efficiency. Under these conditions, the performance of the adsorption column does not depend upon ε(p) or d(p). The relative separation efficiency decreases somewhat and is no longer independent of ε(p) and d(p) when V(f) is increased moderately. At high values of V(f), the relative separation efficiency is unsatisfactory for all cases. The performance of systems with perfusive adsorbent particles is slightly better than the performance of systems with purely diffusive adsorbent particles for some values of V(f).
Recommended Citation
G. A. Heeter and A. I. Liapis, "Multi-Component Perfusion Chromatography in Fixed Bed and Periodic Counter Current Column Operation," Journal of Chromatography A, vol. 734, no. 1, pp. 105 - 123, Elsevier, May 1996.
The definitive version is available at https://doi.org/10.1016/0021-9673(95)01147-1
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Adsorption; Mathematical models; Multi-component adsorption; Perfusion chromatography; Periodic counter-current system
International Standard Serial Number (ISSN)
0021-9673
Document Type
Article - Conference proceedings
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Elsevier, All rights reserved.
Publication Date
17 May 1996
