Mesenchymal Stem Cells and Bioactive Glass Fibers Increase Wound Healing
Department
Biological Sciences
Major
Biological Sciences
Research Advisor
Semon, Julie A.
Advisor's Department
Biological Sciences
Funding Source
Seed Grant from Biomedical Science and Engineering
Abstract
Mesenchymal stem cells (MSCs) have been shown to accelerate wound closure, improve epidermal/dermal architecture, and improve vascular dysregulation. Borate bioactive glass fibers has also successively treated chronic, nonhealing dermal wounds in the clinic. This study analyzes borate bioactive glass activated MSCs and phenotypic alterations. When cocultured with bioactive glass, MSCs have also shown the ability to accelerate wound repair and improve cutaneous architecture while improving vascularity. MSCs in the presence of glass are evaluated for cell growth, differentiation, migration, and invasion. The hypothesis is borate bioactive glass triggers phenotypic changes in MSCs to increase wound healing.
Biography
Lisa Gutgesell is a senior majoring in Biological Science and minoring in Chemistry and Biomedical Engineering. She will be pursuing a PhD in cellular biology.
Presentation Type
OURE Fellows Final Oral Presentation
Document Type
Presentation
Award
2016-2017 OURE Fellows recipient
Location
Turner Room
Presentation Date
17 Apr 2018, 9:30 am - 10:00 am
Mesenchymal Stem Cells and Bioactive Glass Fibers Increase Wound Healing
Turner Room
Mesenchymal stem cells (MSCs) have been shown to accelerate wound closure, improve epidermal/dermal architecture, and improve vascular dysregulation. Borate bioactive glass fibers has also successively treated chronic, nonhealing dermal wounds in the clinic. This study analyzes borate bioactive glass activated MSCs and phenotypic alterations. When cocultured with bioactive glass, MSCs have also shown the ability to accelerate wound repair and improve cutaneous architecture while improving vascularity. MSCs in the presence of glass are evaluated for cell growth, differentiation, migration, and invasion. The hypothesis is borate bioactive glass triggers phenotypic changes in MSCs to increase wound healing.
