Title

Links between Age, White Matter Microstructures, and the SOD2 Allele

Presenter Information

Matthew Healy

Department

Computer Science

Major

Computer Science

Research Advisor

Olbricht, Gayla R.

Advisor's Department

Mathematics and Statistics

Funding Source

OURE

Abstract

Human brains’ structures can change with age and differing health conditions. This study investigates the relationship between age and the presence of the superoxide dismutase 2(SOD2) allele in healthy individuals by using diffusion tensor imaging, or DTI, to measure five different aspects of white matter structural integrity in eight different brain regions. A multivariate analysis of covariance was used to test for differences in structures and SOD2 status while controlling for age. Other statistical methods were performed to test for demographic differences by SOD2 dominance. The results of this study will enable researchers to better understand the association between the SOD2 allele, age, and white matter structural differences in specific brain regions.

Biography

Matthew Healy is a junior in Computer Science and Applied Mathematics. Active on campus, he is the head of a research group for Dr. Markowsky in the Computer Science department, and is secretary of S&T’s Underwater Robotics Team. He is also working on independent projects relating to robotics education and is an undergraduate researcher for the department of applied mathematics and statistics.

Research Category

Sciences

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium

Presentation Date

17 Apr 2018, 9:00 am - 12:00 pm

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Apr 17th, 9:00 AM Apr 17th, 12:00 PM

Links between Age, White Matter Microstructures, and the SOD2 Allele

Upper Atrium

Human brains’ structures can change with age and differing health conditions. This study investigates the relationship between age and the presence of the superoxide dismutase 2(SOD2) allele in healthy individuals by using diffusion tensor imaging, or DTI, to measure five different aspects of white matter structural integrity in eight different brain regions. A multivariate analysis of covariance was used to test for differences in structures and SOD2 status while controlling for age. Other statistical methods were performed to test for demographic differences by SOD2 dominance. The results of this study will enable researchers to better understand the association between the SOD2 allele, age, and white matter structural differences in specific brain regions.