Title

Dynamic Simulation of a Nanorod and a Polymer Molecule in a Microfluidic Device with a Complex Geometry

Presenter Information

Meyyammai Palaniappan
James Jones

Department

Chemical and Biochemical Engineering

Major

Chemical Engineering

Research Advisor

Park, Joontaek

Advisor's Department

Chemical and Biochemical Engineering

Funding Source

OURE

Abstract

Separation of biomolecules and biopolymers through various microfluidic devices has been an area of research that has been under development for its uses in drug delivery and biomolecule behavior. Commercial software is not able to model the intricate dynamics of non-spherical irregular shaped particles, such as a nanorod or a polymer molecule, within these microfluidic devices. The use of COMSOL Multiphysics overcomes these difficulties. A bead-spring model is used to model the polymer molecule and a rigid dumbbell model is used to model a nanorod. The microfluidic device used to model the molecule dynamics is a well in a channel (similar to a dip in a blood vessel). Length of the polymer was varied to study the effect this had on elution time.

Biography

Meyyammai Palaniappan is a senior studying Chemical Engineering and is pursuing minors in Chemistry and Biomedical Engineering. Meyyammai is a member and former president of Missouri S&T iGEM design team. She is also a member of SWE, AiChE, and Missouri S&T’s Honor Academy.

Research Category

Engineering

Presentation Type

Oral Presentation

Document Type

Presentation

Location

Missouri Room

Start Date

4-11-2017 11:30 AM

End Date

4-11-2017 12:00 PM

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Apr 11th, 11:30 AM Apr 11th, 12:00 PM

Dynamic Simulation of a Nanorod and a Polymer Molecule in a Microfluidic Device with a Complex Geometry

Missouri Room

Separation of biomolecules and biopolymers through various microfluidic devices has been an area of research that has been under development for its uses in drug delivery and biomolecule behavior. Commercial software is not able to model the intricate dynamics of non-spherical irregular shaped particles, such as a nanorod or a polymer molecule, within these microfluidic devices. The use of COMSOL Multiphysics overcomes these difficulties. A bead-spring model is used to model the polymer molecule and a rigid dumbbell model is used to model a nanorod. The microfluidic device used to model the molecule dynamics is a well in a channel (similar to a dip in a blood vessel). Length of the polymer was varied to study the effect this had on elution time.