Title

The Effects of Bioglass on Mesenchymal Stem Cells

Presenter Information

Lisa Gutgesell

Department

Biological Sciences

Major

Biological Sciences

Research Advisor

Semon, Julie A.

Advisor's Department

Biological Sciences

Funding Source

Seed Grant from Center for Biomedical Sciences and Engineering

Abstract

Recently, mesenchymal stem cells (MSCs) have been demonstrated to accelerate wound closures, improve epidermal/dermal architecture, and improve vascular dysregulation. Borate-based bioglass has also successfully treated chronic, nonhealing dermal wounds in the clinic. This is due to the ability of bioglass to disintegrate in the body rapidly. This study analyzes bioglass activated MSCs and phenotype alterations to increase wound healing. Protein expression of inflammatory, angiogenic, proliferation, migration, and differentiation factors were compared between MSCs co-cultured with bioglass to MSCs grown under normal conditions. In addition, the type and amount of extracellular matrix deposition, differentiation capacity, angiogenic capacity, and cell proliferation were compared between MSCs co-cultured with bioglass to MSCs grown under normal conditions. This study presents a novel theory and mechanism for the ability of bioglass in wound healing.

Biography

Lisa Gutgesell is a sophomore majoring in Biological Science and minoring in Chemistry at Missouri University of Science and Technology. She spent last summer teaching children the wonders of life science at the Saint Louis Science Center and plans to spend next summer doing breast cancer research at the University of Illinois at Chicago. Lisa hopes to pursue a Ph.D. in cellular biology and continue research, as a professional, after acquiring a Ph.D.

Research Category

Research Proposals

Presentation Type

Poster Presentation

Document Type

Poster

Award

Sciences poster session, Third place

Location

Upper Atrium/Hallway

Presentation Date

11 Apr 2016, 9:00 am - 11:45 am

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Apr 11th, 9:00 AM Apr 11th, 11:45 AM

The Effects of Bioglass on Mesenchymal Stem Cells

Upper Atrium/Hallway

Recently, mesenchymal stem cells (MSCs) have been demonstrated to accelerate wound closures, improve epidermal/dermal architecture, and improve vascular dysregulation. Borate-based bioglass has also successfully treated chronic, nonhealing dermal wounds in the clinic. This is due to the ability of bioglass to disintegrate in the body rapidly. This study analyzes bioglass activated MSCs and phenotype alterations to increase wound healing. Protein expression of inflammatory, angiogenic, proliferation, migration, and differentiation factors were compared between MSCs co-cultured with bioglass to MSCs grown under normal conditions. In addition, the type and amount of extracellular matrix deposition, differentiation capacity, angiogenic capacity, and cell proliferation were compared between MSCs co-cultured with bioglass to MSCs grown under normal conditions. This study presents a novel theory and mechanism for the ability of bioglass in wound healing.