The Effects of Bioglass on Mesenchymal Stem Cells
Department
Biological Sciences
Major
Biological Sciences
Research Advisor
Semon, Julie A.
Advisor's Department
Biological Sciences
Funding Source
Seed Grant from Center for Biomedical Sciences and Engineering
Abstract
Recently, mesenchymal stem cells (MSCs) have been demonstrated to accelerate wound closures, improve epidermal/dermal architecture, and improve vascular dysregulation. Borate-based bioglass has also successfully treated chronic, nonhealing dermal wounds in the clinic. This is due to the ability of bioglass to disintegrate in the body rapidly. This study analyzes bioglass activated MSCs and phenotype alterations to increase wound healing. Protein expression of inflammatory, angiogenic, proliferation, migration, and differentiation factors were compared between MSCs co-cultured with bioglass to MSCs grown under normal conditions. In addition, the type and amount of extracellular matrix deposition, differentiation capacity, angiogenic capacity, and cell proliferation were compared between MSCs co-cultured with bioglass to MSCs grown under normal conditions. This study presents a novel theory and mechanism for the ability of bioglass in wound healing.
Biography
Lisa Gutgesell is a sophomore majoring in Biological Science and minoring in Chemistry at Missouri University of Science and Technology. She spent last summer teaching children the wonders of life science at the Saint Louis Science Center and plans to spend next summer doing breast cancer research at the University of Illinois at Chicago. Lisa hopes to pursue a Ph.D. in cellular biology and continue research, as a professional, after acquiring a Ph.D.
Research Category
Research Proposals
Presentation Type
Poster Presentation
Document Type
Poster
Award
Sciences poster session, Third place
Location
Upper Atrium/Hallway
Presentation Date
11 Apr 2016, 9:00 am - 11:45 am
The Effects of Bioglass on Mesenchymal Stem Cells
Upper Atrium/Hallway
Recently, mesenchymal stem cells (MSCs) have been demonstrated to accelerate wound closures, improve epidermal/dermal architecture, and improve vascular dysregulation. Borate-based bioglass has also successfully treated chronic, nonhealing dermal wounds in the clinic. This is due to the ability of bioglass to disintegrate in the body rapidly. This study analyzes bioglass activated MSCs and phenotype alterations to increase wound healing. Protein expression of inflammatory, angiogenic, proliferation, migration, and differentiation factors were compared between MSCs co-cultured with bioglass to MSCs grown under normal conditions. In addition, the type and amount of extracellular matrix deposition, differentiation capacity, angiogenic capacity, and cell proliferation were compared between MSCs co-cultured with bioglass to MSCs grown under normal conditions. This study presents a novel theory and mechanism for the ability of bioglass in wound healing.
