Title

CFD Simulation Study of Interstitial Nanoparticle Flow in Tumor-On-A-Chip

Presenter Information

Melissa Vidal

Department

Chemical and Biochemical Engineering

Major

Chemical Engineering

Research Advisor

Park, Joontaek

Advisor's Department

Chemical and Biochemical Engineering

Abstract

We performed a computational fluid dynamics simulation to study the flow of nanoparticles in a microfluidic device, which mimics the cross section of a tumor tissue. A tumor is a complex phenomenon with vasculatures that have micro-sized gaps in their endothelial cells, also known as the enhanced permeability and retention effect (EPR). This allows the enhancement of transport of nutrients and oxygen. For the efficient study of drug delivery to tumor cells, and to also avoid complicated and costly animal studies, a tumor-on-a-chip device, which consists of a tumor tissue microchamber surrounded by porous microarrays, is under development. CFD simulation was performed to investigate the flow behavior of drug delivery nanoparticles in that device. More specifically, we estimated the permeability of nanoparticles from microchannel (mimicking blood stream) to the tumor chamber through the porous arrays. The outcome can be used in mathematical modeling of the system as well as validation of the performance of the tumor-on-a-chip device.

Biography

Melissa Vidal is currently a senior in Chemical Engineering at Missouri S&T. Melissa has worked with Dr. Joontaek Park on the CFD simulation project since January 2016. Her contributions include building a simpler geometry to perform the CFD, and running the simulation at different particle sizes. She has also worked with Dr. Smith on the biodiesel production project since August 2013. She will start graduate school in Fall 2016 to pursue her Ph.D. in Chemical Engineering.

Research Category

Engineering

Presentation Type

Oral Presentation

Document Type

Presentation

Award

Engineering oral presentation, Third place

Location

Turner Room

Presentation Date

11 Apr 2016, 11:20 am - 11:40 am

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Apr 11th, 11:20 AM Apr 11th, 11:40 AM

CFD Simulation Study of Interstitial Nanoparticle Flow in Tumor-On-A-Chip

Turner Room

We performed a computational fluid dynamics simulation to study the flow of nanoparticles in a microfluidic device, which mimics the cross section of a tumor tissue. A tumor is a complex phenomenon with vasculatures that have micro-sized gaps in their endothelial cells, also known as the enhanced permeability and retention effect (EPR). This allows the enhancement of transport of nutrients and oxygen. For the efficient study of drug delivery to tumor cells, and to also avoid complicated and costly animal studies, a tumor-on-a-chip device, which consists of a tumor tissue microchamber surrounded by porous microarrays, is under development. CFD simulation was performed to investigate the flow behavior of drug delivery nanoparticles in that device. More specifically, we estimated the permeability of nanoparticles from microchannel (mimicking blood stream) to the tumor chamber through the porous arrays. The outcome can be used in mathematical modeling of the system as well as validation of the performance of the tumor-on-a-chip device.