CFD Simulation Study of Interstitial Nanoparticle Flow in Tumor-On-A-Chip
Department
Chemical and Biochemical Engineering
Major
Chemical Engineering
Research Advisor
Park, Joontaek
Advisor's Department
Chemical and Biochemical Engineering
Abstract
We performed a computational fluid dynamics simulation to study the flow of nanoparticles in a microfluidic device, which mimics the cross section of a tumor tissue. A tumor is a complex phenomenon with vasculatures that have micro-sized gaps in their endothelial cells, also known as the enhanced permeability and retention effect (EPR). This allows the enhancement of transport of nutrients and oxygen. For the efficient study of drug delivery to tumor cells, and to also avoid complicated and costly animal studies, a tumor-on-a-chip device, which consists of a tumor tissue microchamber surrounded by porous microarrays, is under development. CFD simulation was performed to investigate the flow behavior of drug delivery nanoparticles in that device. More specifically, we estimated the permeability of nanoparticles from microchannel (mimicking blood stream) to the tumor chamber through the porous arrays. The outcome can be used in mathematical modeling of the system as well as validation of the performance of the tumor-on-a-chip device.
Biography
Melissa Vidal is currently a senior in Chemical Engineering at Missouri S&T. Melissa has worked with Dr. Joontaek Park on the CFD simulation project since January 2016. Her contributions include building a simpler geometry to perform the CFD, and running the simulation at different particle sizes. She has also worked with Dr. Smith on the biodiesel production project since August 2013. She will start graduate school in Fall 2016 to pursue her Ph.D. in Chemical Engineering.
Research Category
Engineering
Presentation Type
Oral Presentation
Document Type
Presentation
Award
Engineering oral presentation, Third place
Location
Turner Room
Presentation Date
11 Apr 2016, 11:20 am - 11:40 am
CFD Simulation Study of Interstitial Nanoparticle Flow in Tumor-On-A-Chip
Turner Room
We performed a computational fluid dynamics simulation to study the flow of nanoparticles in a microfluidic device, which mimics the cross section of a tumor tissue. A tumor is a complex phenomenon with vasculatures that have micro-sized gaps in their endothelial cells, also known as the enhanced permeability and retention effect (EPR). This allows the enhancement of transport of nutrients and oxygen. For the efficient study of drug delivery to tumor cells, and to also avoid complicated and costly animal studies, a tumor-on-a-chip device, which consists of a tumor tissue microchamber surrounded by porous microarrays, is under development. CFD simulation was performed to investigate the flow behavior of drug delivery nanoparticles in that device. More specifically, we estimated the permeability of nanoparticles from microchannel (mimicking blood stream) to the tumor chamber through the porous arrays. The outcome can be used in mathematical modeling of the system as well as validation of the performance of the tumor-on-a-chip device.
