Effects of B3 Bioactive Glass Length on in Vivo Angiogenesis
Department
Biological Sciences
Major
Pre-medical Chemistry and Biology
Research Advisor
Day, D. E.
Mohammadkhah, Ali
Advisor's Department
Materials Science and Engineering
Funding Source
OURE Fellows Program Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program
Abstract
Borate-based 13-93 B3 bioactive glass scaffolds have been shown to promote angiogenesis in vivo and have been used successfully in clinical trials for wound healing. This study will investigate various scaffold lengths in order to determine the maximum length that a glass scaffold may be before angiogenesis is no longer present within the scaffold. Two separate 13-93 B3 bioactive glass compositions will be compared in this experiment--one with the inclusion of copper and one without--while using the same experimental design of varying scaffold length in order to determine the effects that the addition of copper may have on angiogenic promotion. Toxicological analysis will be conducted per each bioactive glass composition in order to determine the effects that each composition has in vivo.
Biography
Caleb Trecazzi is a junior who is pursuing a dual bachelor’s degree in pre-medical chemistry and biology. He has assisted in the iGEM laboratory under the supervision of Levi Palmer, the current iGEM Laboratory Manager, in performing gel electrophoresis, cell culture preparation and plating, and briefly in the creation of competent cells. He has taken and successfully completed a research course (Math 390, Summer 2010) with Dr. Matt Insall in the mathematics department. Together their research team studied lattice theory, nonstandard analysis, and did minor work with a project titled “The Book of Squares.”
Research Category
Sciences
Presentation Type
OURE Fellows Proposal Oral Applicant
Document Type
Presentation
Award
Fellows 14-15 Awarded
Location
Turner Room
Presentation Date
16 Apr 2014, 2:00 pm - 2:20 pm
Effects of B3 Bioactive Glass Length on in Vivo Angiogenesis
Turner Room
Borate-based 13-93 B3 bioactive glass scaffolds have been shown to promote angiogenesis in vivo and have been used successfully in clinical trials for wound healing. This study will investigate various scaffold lengths in order to determine the maximum length that a glass scaffold may be before angiogenesis is no longer present within the scaffold. Two separate 13-93 B3 bioactive glass compositions will be compared in this experiment--one with the inclusion of copper and one without--while using the same experimental design of varying scaffold length in order to determine the effects that the addition of copper may have on angiogenic promotion. Toxicological analysis will be conducted per each bioactive glass composition in order to determine the effects that each composition has in vivo.
Comments
Joint project with Anthony Bitar