Effects of B3 Bioactive Glass Length on in Vivo Angiogenesis
Department
Biological Sciences
Major
Pre-medical Biology
Research Advisor
Day, D. E.
Mohammadkhah, Ali
Advisor's Department
Materials Science and Engineering
Funding Source
OURE Fellows Program Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program
Abstract
Borate-based 13-93 B3 bioactive glass scaffolds have been shown to promote angiogenesis in vivo and have been used successfully in clinical trials for wound healing. This study will investigate various scaffold lengths in order to determine the maximum length that a glass scaffold may be before angiogenesis is no longer present within the scaffold. Two separate 13-93 B3 bioactive glass compositions will be compared in this experiment--one with the inclusion of copper and one without--while using the same experimental design of varying scaffold length in order to determine the effects that the addition of copper may have on angiogenic promotion. Toxicological analysis will be conducted per each bioactive glass composition in order to determine the effects that each composition has in vivo.
Biography
Anthony Bitar is a freshman who is pursuing a pre-medical bachelor’s degree in the biological sciences department. He has worked alongside Ali Mohammadkhah, a graduate student in the Materials Sciences and Engineering department, since September 2013 and has learned cell culturing techniques as well as how to prepare and produce bioactive glass and fibers. He has assisted in implanting scaffolds in Sprague Dawley laboratory rats in order to study angiogenesis with different bioactive glass compositions. He is currently learning about tissue processing.
Research Category
Sciences
Presentation Type
OURE Fellows Proposal Oral Applicant
Document Type
Presentation
Location
Turner Room
Presentation Date
16 Apr 2014, 2:00 pm - 2:20 pm
Effects of B3 Bioactive Glass Length on in Vivo Angiogenesis
Turner Room
Borate-based 13-93 B3 bioactive glass scaffolds have been shown to promote angiogenesis in vivo and have been used successfully in clinical trials for wound healing. This study will investigate various scaffold lengths in order to determine the maximum length that a glass scaffold may be before angiogenesis is no longer present within the scaffold. Two separate 13-93 B3 bioactive glass compositions will be compared in this experiment--one with the inclusion of copper and one without--while using the same experimental design of varying scaffold length in order to determine the effects that the addition of copper may have on angiogenic promotion. Toxicological analysis will be conducted per each bioactive glass composition in order to determine the effects that each composition has in vivo.
Comments
Joint project with Caleb Trecazzi