Title

Effects of B3 Bioactive Glass Length on in Vivo Angiogenesis

Presenter Information

Anthony Bitar

Department

Biological Sciences

Major

Pre-medical Biology

Research Advisor

Day, D. E.
Mohammadkhah, Ali

Advisor's Department

Materials Science and Engineering

Funding Source

OURE Fellows Program Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program

Abstract

Borate-based 13-93 B3 bioactive glass scaffolds have been shown to promote angiogenesis in vivo and have been used successfully in clinical trials for wound healing. This study will investigate various scaffold lengths in order to determine the maximum length that a glass scaffold may be before angiogenesis is no longer present within the scaffold. Two separate 13-93 B3 bioactive glass compositions will be compared in this experiment--one with the inclusion of copper and one without--while using the same experimental design of varying scaffold length in order to determine the effects that the addition of copper may have on angiogenic promotion. Toxicological analysis will be conducted per each bioactive glass composition in order to determine the effects that each composition has in vivo.

Biography

Anthony Bitar is a freshman who is pursuing a pre-medical bachelor’s degree in the biological sciences department. He has worked alongside Ali Mohammadkhah, a graduate student in the Materials Sciences and Engineering department, since September 2013 and has learned cell culturing techniques as well as how to prepare and produce bioactive glass and fibers. He has assisted in implanting scaffolds in Sprague Dawley laboratory rats in order to study angiogenesis with different bioactive glass compositions. He is currently learning about tissue processing.

Research Category

Sciences

Presentation Type

OURE Fellows Proposal Oral Applicant

Document Type

Presentation

Location

Turner Room

Presentation Date

16 Apr 2014, 2:00 pm - 2:20 pm

Comments

Joint project with Caleb Trecazzi

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Apr 16th, 2:00 PM Apr 16th, 2:20 PM

Effects of B3 Bioactive Glass Length on in Vivo Angiogenesis

Turner Room

Borate-based 13-93 B3 bioactive glass scaffolds have been shown to promote angiogenesis in vivo and have been used successfully in clinical trials for wound healing. This study will investigate various scaffold lengths in order to determine the maximum length that a glass scaffold may be before angiogenesis is no longer present within the scaffold. Two separate 13-93 B3 bioactive glass compositions will be compared in this experiment--one with the inclusion of copper and one without--while using the same experimental design of varying scaffold length in order to determine the effects that the addition of copper may have on angiogenic promotion. Toxicological analysis will be conducted per each bioactive glass composition in order to determine the effects that each composition has in vivo.