Title

Identifying Novel Genes of Waking in Drosophila

Presenter Information

Anna Luce

Department

Biological Sciences

Major

Biological Sciences

Research Advisor

Thimgan, Matthew S.

Advisor's Department

Biological Sciences

Abstract

Sleeping is a cyclic process regulated by our circadian rhythms and our sleep need, thus "clock" genes are a critical player in this process. One cause of the sleep disorder, insomnia, is attributed to heightened arousal of waking pathways, resulting in overactive waking instead of deficit in sleep. Genes involved in the waking process in humans can be studied in the model organism, Drosophila melanogaster (fruit flies), which have similar mechanism for regulating sleep. To identify novel genes involved in sleep regulation and waking pathways, we have mutagenized the genome of Drosophila with a chemical mutagen, Ethylmethane Sultanate (EMS). These mutants are then screened for differences in their ability to respond to arousing stimuli, such as light and food. These experiments identified mutants with deficits in waking in response to stimuli and will give insight to why people have trouble initiating, maintaining, or have an insufficient duration of sleep.

Biography

Anna is a junior in Missouri S& T's Biology department, and works in the Drosophila Sleep Behavior Lab as well as being involved in many campus based organizations. Her biological interests include pre-medicine, emphasizing ophthalmology.

Research Category

Sciences

Presentation Type

Oral Presentation

Document Type

Presentation

Location

Upper Atrium/Hallway

Presentation Date

03 Apr 2013, 9:00 am - 11:45 am

Comments

Joint project with Candace Miller

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Apr 3rd, 9:00 AM Apr 3rd, 11:45 AM

Identifying Novel Genes of Waking in Drosophila

Upper Atrium/Hallway

Sleeping is a cyclic process regulated by our circadian rhythms and our sleep need, thus "clock" genes are a critical player in this process. One cause of the sleep disorder, insomnia, is attributed to heightened arousal of waking pathways, resulting in overactive waking instead of deficit in sleep. Genes involved in the waking process in humans can be studied in the model organism, Drosophila melanogaster (fruit flies), which have similar mechanism for regulating sleep. To identify novel genes involved in sleep regulation and waking pathways, we have mutagenized the genome of Drosophila with a chemical mutagen, Ethylmethane Sultanate (EMS). These mutants are then screened for differences in their ability to respond to arousing stimuli, such as light and food. These experiments identified mutants with deficits in waking in response to stimuli and will give insight to why people have trouble initiating, maintaining, or have an insufficient duration of sleep.