Title

Aerogels as Drug Delivery Systems: Silica and Dysprosia Aerogels as Drug Carriers for Indomethacin and Paracetamol

Presenter Information

Brice Curtin

Department

Chemistry

Major

Chemistry

Research Advisor

Sotiriou-Leventis, Lia

Advisor's Department

Chemistry

Funding Source

Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program; ARO and NSF

Abstract

The use of aerogels as drug delivery systems is fast growing as an attractive field of research because of their high surface area and low density. This project is on the feasibility of a system of aerogels and pharmaceutical drugs combined in a novel way. Two drugs were investigated: paracetamol and indomethacin; and two biocompatible aerogels (silica and dysprosia based) were loaded with the aforementioned drugs. We found that silica aerogels could be loaded with 13.6% paracetamol and 12.1% indomethacin, while polymer crosslinked dysprosium oxide (X-DyOx) aerogels could be loaded with 35.1% paracetamol and 32.2% indomethacin. We then time-released the drugs from each aerogel in two buffer systems (0.1 N HCl and phosphate pH = 7.4). The silica aerogels showed a total drug release in 0.5 h in each system. However, XDyOx completely released paracetamol in 60 h in 0.1 N HCl and 65 h in the phosphate buffer.

Biography

Brice is a current junior in Chemistry at Missouri University of Science and Technology in Rolla, MO. He has worked under the guidance of Dr. Chariklia Sotiriou-Leventis on aerogel systems and pharmaceutical applications since January 2010. He plans on attending graduate school and pursuing further research opportunities after graduation.

Research Category

Sciences

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium/Hallway

Presentation Date

06 Apr 2011, 9:00 am - 11:45 am

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Apr 6th, 9:00 AM Apr 6th, 11:45 AM

Aerogels as Drug Delivery Systems: Silica and Dysprosia Aerogels as Drug Carriers for Indomethacin and Paracetamol

Upper Atrium/Hallway

The use of aerogels as drug delivery systems is fast growing as an attractive field of research because of their high surface area and low density. This project is on the feasibility of a system of aerogels and pharmaceutical drugs combined in a novel way. Two drugs were investigated: paracetamol and indomethacin; and two biocompatible aerogels (silica and dysprosia based) were loaded with the aforementioned drugs. We found that silica aerogels could be loaded with 13.6% paracetamol and 12.1% indomethacin, while polymer crosslinked dysprosium oxide (X-DyOx) aerogels could be loaded with 35.1% paracetamol and 32.2% indomethacin. We then time-released the drugs from each aerogel in two buffer systems (0.1 N HCl and phosphate pH = 7.4). The silica aerogels showed a total drug release in 0.5 h in each system. However, XDyOx completely released paracetamol in 60 h in 0.1 N HCl and 65 h in the phosphate buffer.