Title

Is Hof1 a Dbf2 Target?

Presenter Information

Benjamin Hale

Department

Biological Sciences

Major

Biology

Research Advisor

Shannon, Katie

Advisor's Department

Biological Sciences

Funding Source

Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program

Abstract

Hof1 is a member of the Pombe Cdc15 homology (PCH) family, a conserved family of genes involved in cytokinesis in yeast and mammalian cells. Cytokinesis is the physical separation of one cell into two, accomplished by contraction of a ring composed of Factin and type II myosin. In budding yeast, Hof1 is required for normal contraction of the actomyosin ring and accompanying septum deposition. The phosphorylation of Hof1 during mitosis has been shown to be mitotic exit network (MEN) dependent. The goal of this study is to show if Hof1 is a target of the MEN kinase, Dbf2.

Biography

Benjamin Hale is at his fourth and final year at Missouri University of Science and Technology. He has done two prior OURE’s in environmental microbiology, has been employed as a research assistant on campus, and participated in a summer research internship through Iowa State University Interdepartmental Genetics Program.

Research Category

Sciences

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium/Hallway

Presentation Date

07 Apr 2010, 9:00 am - 11:45 am

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Apr 7th, 9:00 AM Apr 7th, 11:45 AM

Is Hof1 a Dbf2 Target?

Upper Atrium/Hallway

Hof1 is a member of the Pombe Cdc15 homology (PCH) family, a conserved family of genes involved in cytokinesis in yeast and mammalian cells. Cytokinesis is the physical separation of one cell into two, accomplished by contraction of a ring composed of Factin and type II myosin. In budding yeast, Hof1 is required for normal contraction of the actomyosin ring and accompanying septum deposition. The phosphorylation of Hof1 during mitosis has been shown to be mitotic exit network (MEN) dependent. The goal of this study is to show if Hof1 is a target of the MEN kinase, Dbf2.