Title

Drugs Associated with Fatal Cutaneous Reactions: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Presenter Information

John Krumme

Department

Biological Sciences

Major

Chemical Engineering

Research Advisor

Stoecker, William V.

Advisor's Department

Electrical and Computer Engineering

Funding Source

Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Fellows Program; DERMVIS Research Group

Abstract

Two severe drug reactions, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) were analyzed using the FDA’s Adverse Events Reporting System’s (AERS) drug reports from 2004 to 2008. Drugs were identified as being at risk by analyzing the number of reported cases of SJS and TEN with serious and fatal outcomes for drugs with a significant proportional relative risk (PRR > 2.0). The study resulted in the discovery of primary suspect drugs in the top ten list of fatal outcome SJS-TEN cases. These drugs were not previously suspected to have significant SJSTEN risk. The drugs include furosemide (PRR=6.6), ciprofloxacin (PRR=5.6), and ibuprofen (PRR=5.8). The data gathered from this study could be duplicated for other serious drug reaction leading to serious outcomes and death and made available to physicians through an online database.

Biography

John Krumme is a senior at Missouri S&T majoring in Chemical Engineering with a minor in Biological Science. Along with working with the DERMVIS, Krumme is active on campus as a student-athlete on the Miner’s Men’s Football Team, served as the president of Tau Beta Pi, participated as an active member of the school’s pre-medical society (SCRUBS), and is an active member of Sigma Phi Epsilon. Krumme is also a member of the Mentoring Makes a Difference outreach program put on by Prevention Consultants for Missouri. Krumme will graduate in May, 2010, and will attend medical school in August at the University of Missouri.

Research Category

Engineering

Presentation Type

Oral Presentation

Document Type

Presentation

Location

Gasconade Room

Presentation Date

07 Apr 2010, 10:30 am - 11:00 am

Comments

Joint project with Thomas McKinnon

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Apr 7th, 10:30 AM Apr 7th, 11:00 AM

Drugs Associated with Fatal Cutaneous Reactions: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Gasconade Room

Two severe drug reactions, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) were analyzed using the FDA’s Adverse Events Reporting System’s (AERS) drug reports from 2004 to 2008. Drugs were identified as being at risk by analyzing the number of reported cases of SJS and TEN with serious and fatal outcomes for drugs with a significant proportional relative risk (PRR > 2.0). The study resulted in the discovery of primary suspect drugs in the top ten list of fatal outcome SJS-TEN cases. These drugs were not previously suspected to have significant SJSTEN risk. The drugs include furosemide (PRR=6.6), ciprofloxacin (PRR=5.6), and ibuprofen (PRR=5.8). The data gathered from this study could be duplicated for other serious drug reaction leading to serious outcomes and death and made available to physicians through an online database.