Title

Cytokinesis Defects in Budding Yeast

Presenter Information

Katherine Stockstill

Department

Biological Sciences

Major

Biological Sciences

Research Advisor

Shannon, Katie

Advisor's Department

Biological Sciences

Funding Source

Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program

Abstract

Budding yeast are a very good research organism, because they are similar to humans in many ways. One of the research opportunities with budding yeast is that there are many genes that are uncharacterized, and it is not known what their cellular function is or what their functional role is. There are also many genes that are affected by phosphorylation, one such gene is HOF1. Hof1 is phosphorylated during mitosis and results have shown that a Hof1 mutant without a PEST domain affects Hof1-GFP dynamics during cytokinesis. It has also been shown that deletion of the PEST domain may prevent phosphorylation of Hof1 (Blondel et al., 2005). Cytokinesis is the division of a cell into two daughter cells. Our research lab is interested in cytokinesis, because cytokinesis defects can lead to polyploidy in the cell. This defect can lead to cancer or cell death.

Biography

Katherine Stockstill is a graduating senior majoring in Biological Sciences. On campus, Katherine is member Kappa Delta Sorority, Helix, and Phi Sigma. She also has an OURE for her research in the Cytokinesis Lab. Katherine is also a waitress at Applebee’s. After graduation Katherine is planning on going onto graduate school, where she will pursue a master’s degree.

Research Category

Sciences

Presentation Type

Oral Presentation

Document Type

Presentation

Award

Sciences oral presentation, Third place

Location

Turner Room

Presentation Date

08 Apr 2009, 10:00 am - 10:30 am

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Apr 8th, 10:00 AM Apr 8th, 10:30 AM

Cytokinesis Defects in Budding Yeast

Turner Room

Budding yeast are a very good research organism, because they are similar to humans in many ways. One of the research opportunities with budding yeast is that there are many genes that are uncharacterized, and it is not known what their cellular function is or what their functional role is. There are also many genes that are affected by phosphorylation, one such gene is HOF1. Hof1 is phosphorylated during mitosis and results have shown that a Hof1 mutant without a PEST domain affects Hof1-GFP dynamics during cytokinesis. It has also been shown that deletion of the PEST domain may prevent phosphorylation of Hof1 (Blondel et al., 2005). Cytokinesis is the division of a cell into two daughter cells. Our research lab is interested in cytokinesis, because cytokinesis defects can lead to polyploidy in the cell. This defect can lead to cancer or cell death.