Conversion of Melt-Derived Microfibrous Borate (13-93B3) and Silicate (45S5) Bioactive Glass in a Simulated Body Fluid


Microfibrous bioactive glasses are showing a considerable capacity to heal soft tissue wounds, but little information is available on the mechanism of healing. In the present study, the conversion of microfibrous borate bioactive glass (diameter = 0.2-5 μm) with the composition designated 13-93B3 (5.5 Na2O, 11.1 K2O, 4.6 MgO, 18.5 CaO, 3.7 P2O 5, 56.6 B2O3 wt%) was evaluated in vitro as a function of immersion time in a simulated body fluid (SBF) at 37 C using structural and chemical techniques. Silicate 45S5glass microfibers (45 SiO 2, 24.5 Na2O, 24.5 CaO, 6 P2O5 wt%) were also studied for comparison. Microfibrous 13-93B3 glass degraded almost completely and converted to a calcium phosphate material within 7-14 days in SBF, whereas >85 % of the silica remained in the 45S5 microfibers, forming a silica gel phase. An amorphous calcium phosphate (ACP) product that formed on the 13-93B3 microfibers crystallized at a slower rate to hydroxyapatite (HA) when compared to the ACP that formed on the 45S5 fibers. For immersion times >3 days, the 13-93B3 fibers released a higher concentration of Ca into the SBF than the 45S5 fibers. The fast and more complete degradation, slow crystallization of the ACP product, and higher concentration of dissolved Ca in SBF could contribute to the capacity of the microfibrous borate 13-93B3 glass to heal soft tissue wounds.


Nuclear Engineering and Radiation Science

Second Department

Materials Science and Engineering

Keywords and Phrases

Biomaterials; Polymer Sciences; Ceramics-Glass-Composites-Natural Methods; Metallic Materials; Characterization and Evaluation of Materials; Surfaces and Interfaces-Thin Films

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Document Type

Article - Journal

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© 2013 Springer Verlag, All rights reserved.

Publication Date

01 Jan 2013